FOR IMMEDIATE RELEASE                                                                   Contact:  Neal G. Koller
                                                                                                                              President & CEO
27 December 2007                                                                                               Board of Directors
                                                                                                                              443 994 0101
    
                         PLUROGEN THERAPEUTICS INC. AND WELCARE INDUSTRIES, S.p.a.
                                                  SIGN LETTER OF INTENT TO
                        COMMERCIALIZE NEW PRODUCTS UTILIZING PLUROGEN TECHNOLOGY

(Charlottesville, VA, December 27, 2007) – PluroGen Therapeutics, Inc. today announced a Letter of Intent with
Welcare Industries S.p.a. (Orvieto, Italy) to develop and commercialize new wound and skin cleansing products
based on PluroGen’s proprietary topical gel technology and for Welcare to distribute PluroGen products.

Commenting on the Letter of Intent, Neal G. Koller, President & CEO of PluroGen, said, “Establishing a
development and commercialization relationship with Welcare is very strategic and an important progress step
for PluroGen.  Welcare is an established European leader in wound and skin cleansing products and technology.  
This relationship will broaden our product offerings and facilitate PluroGen’s entry into the European market.”

Fulvia Lazzarotto, Managing Director for Welcare, commented that “we are very excited to establish a
relationship with PluroGen.  PluroGen technology and products will provide Welcare with new, differentiated and
superior products for our customers and their patients.”

About PluroGen Therapeutics, Inc.
PluroGen is a wound healing company commercializing its patent-protected gel technology platform that provides
superior and differentiated physical and bio-impact benefits to wound healing.  The technology is configurable to
deliver drug and non-drug compounds as protected and advanced therapeutic products for simple and complex
wound healing.  PluroGen’s product pipeline targets improved, protected therapies for the 6 Areas of Therapeutic
Treatment of tissue healing (cleansing, infection, pain, inflammation, tissue salvage, tissue regeneration).

PluroGen’s first gel, PluroGel™, is being used initially for two branded topical antimicrobial products, PluroGel™
Silver Sulfadiazine and PluroGel™ TAG.  PluroGel™ TAG is currently in routine use at the University of Virginia
Medical Center, having shown superior results on more than 2,000 patients in two different patient populations,
severe burns and chronic wounds.  The PluroGen management and operational teams, Boards and Principal
Investigators are recognized global clinical and commercial leaders in PluroGen’s target markets of burn and
wound care and in the life sciences industry.

For more information about PluroGen Therapeutics, Inc., visit the Company’s web site at www.plurogen.com.

About the Welcare Industries, S.p.a.
Welcare Industries, S.p.a. is a privately held European medical device company with manufacturing, distribution
and headquarters in Orvieto, Italy.  Welcare was founded in 1997 and focuses on wound and total patient
cleansing products, clinical and patient protection products and specialty procedure products.  Welcare is
currently selling its products in major European countries.

For more information about Welcare Industries, S.p.a., visit the Company’s web site at www.welcaremedical.com.

Statements included in this press release that are not historical in nature are "forward-looking statements" within the
meaning of the Private Securities Litigation Reform Act of 1995.  The Company cautions readers that forward-looking
statements are subject to certain risks and uncertainties, which could cause actual results to differ materially and
which are identified from time to time in the Company’s reports filed with the U.S. Securities and Exchange
Commission.  PluroGen Therapeutics, Inc. claims the protection of the Safe Harbor for forward-looking statements
contained in the Private Securities Litigation Reform Act of 1995.

Information included on PluroGen Therapeutics, Inc website or Welcare Industries, S.p.a website is not incorporated herein by
reference or otherwise.
PluroGen Therapeutics, Inc.
503 Broadleaf Way
Charlottesville, VA  22911
Tel:  443 994 0101
Fax:  410 990 9817
www.plurogen.com
News Release